Major carriers relevant to the TYS→COU route include American Airlines (via American Eagle connections), Delta Air Lines (via Delta Connection hubs), and United Airlines (via United Express through regional hubs). Allegiant operates leisure routes out of McGhee Tyson Airport (TYS) but typically to leisure destinations rather than Columbia Regional Airport (COU). In November, American may offer convenient connections through DFW or CLT, Delta through ATL, and United through ORD or DEN depending on routing. Compare total travel time, baggage fees, and on-time performance for November travel—American can have competitive schedules to COU, Delta often offers frequent connections through ATL, and United may provide varied routing options. For travelers prioritizing speed, look for the shortest total itinerary with a single connection; for budget-conscious flyers, evaluate bundled fare options and loyalty benefits.