Major carriers offering SNA→BUF itineraries in September often include American Airlines, Delta Air Lines, and United Airlines via their respective hubs (DFW, ATL, ORD, DEN). Low-cost carriers may serve SNA with connections to partner airlines for transcontinental travel. Compare ticket prices, layover durations, baggage allowances, and elite status perks when choosing. For example, United often connects via Denver for efficient west-to-east routing, while American routes through Dallas/Fort Worth. Use each airline’s flexible search tools to filter one-stop vs two-stop options and to view total travel time vs price trade-offs.