Major carriers that operate between Raleigh-Durham International Airport (RDU) and Syracuse Hancock International Airport (SYR) include American Airlines, Delta Air Lines, and United Airlines, often offering one-stop options via their hub cities; JetBlue and Southwest may offer competitive itineraries when including nearby airports. American tends to route passengers through Charlotte or Philadelphia, Delta through Atlanta or Detroit, and United through Chicago or Newark—each hub has different winter reliability records. Compare seat types, baggage fees, and elite benefits; if avoiding weather risk is important, choose carriers with strong on-time performance at winter-prone hubs and consider flexible or refundable fare classes. CTA: Compare carrier options for Raleigh-Durham International Airport (RDU) to Syracuse Hancock International Airport (SYR) and book the airline that best matches your travel priorities this December.