Major carriers commonly used between Chicago O'Hare International Airport (ORD) and Johannesburg (All Airports) (JNBA) include British Airways (one-stop via London), Lufthansa (via Frankfurt), Qatar Airways (via Doha), KLM (via Amsterdam), and United (via U.S. or European hubs). British Airways often provides convenient overnight schedules with competitive business-class fares; Lufthansa and KLM offer consistent transatlantic connections and solid lounge access in Europe. Qatar Airways provides high service levels through Doha and may offer competitive shoulder-season pricing in May. When comparing, factor in baggage allowances, change fees, on-time performance, and total journey time. Use sample searches and check alliance partners for through-checked baggage and coordinated transfers.