When comparing airlines for December travel from Chicago Midway International Airport (MDW) to Gainesville Regional Airport (GNV), evaluate total trip cost (including baggage and seat fees), typical connection hubs, and on-time performance during winter months. Major carriers that commonly service routes to GNV use hubs like Atlanta, Charlotte, and Dallas, offering loyalty program benefits and more frequent schedules. Budget carriers flying from MDW may offer lower base fares but charge for checked bags and seat assignments, so weigh convenience against savings. Use the airline filter in your flight search to compare fees and book the option that best aligns with your priorities — price, speed, or baggage friendliness.