Popular carriers for the Orlando International Airport (MCO) to Istanbul Airport (IST) route in October include Turkish Airlines (via partner gateways), Lufthansa (via Frankfurt), British Airways (via London), Qatar Airways (via Doha), and major U.S. carriers like Delta and American with partner connections. Turkish Airlines often provides strong long-haul service quality and network access within Turkey; Lufthansa and British Airways offer reliable European hub connections. Qatar Airways can be a comfortable alternative with a one-stop via Doha. When comparing airlines, consider total travel time, layover length, included baggage allowance, in-flight amenities, and connectivity to your final Turkish destination. Use keywords like "best airline Orlando Istanbul" and "MCO IST airline comparison" while collecting quotes.