When choosing an airline for MBS International Airport (MBS) to Chicago (All Airports) (CHIA) in January, evaluate service frequency, hub connections, and winter reliability. Major carriers that commonly serve regional Midwest routes include American Airlines (connecting via ORD and PHL), United Airlines (via ORD), and Delta Air Lines (via DTW). American and United often provide multiple daily options into Chicago O'Hare, while Delta can offer reliable one-stop options through Detroit. Compare baggage fees, seat selection options, and on-time performance for January travel. For the best reliability in winter, choose carriers with strong recovery resources at Chicago hubs. CTA: Compare airline schedules and book the best January option now.