Average airborne time from Blue Grass Airport (LEX) to Phoenix Sky Harbor International Airport (PHX) is about 4.5–5 hours (block-to-block excludes layovers). Because most LEX to PHX itineraries require one connection, total travel time commonly ranges from 6 to 9 hours depending on layover length. Common one-stop hubs include Atlanta (ATL), Charlotte (CLT), Dallas-Fort Worth (DFW), and Chicago-O'Hare (ORD). Sample November itineraries: LEX→ATL (1.5 hours) layover 90–120 minutes → ATL→PHX (4 hours), total ~7 hours; or LEX→DFW (1.5 hours) layover 60–90 minutes → DFW→PHX (3.5–4 hours), total ~6.5–7.5 hours. For best connections in November, prioritize minimum 60–90 minute domestic transfer windows and watch for schedule changes around the Thanksgiving holiday and daylight saving time transition.