Delta Air Lines typically offers the most nonstop options between Los Angeles International Airport (LAX) and Detroit Metropolitan Wayne County Airport (DTW), with full-service amenities, loyalty benefits, and bundled fare options. American and United often provide one-stop itineraries via their respective hubs (Chicago, Dallas, or Phoenix) and can be competitive on price and schedule flexibility. Spirit Airlines may offer lower base fares on one-stop routes but charges for seat selection, carry-ons, and other services—making total price comparison important. For November travel, evaluate fare classes, baggage fees, and rebooking flexibility; Delta nonstops are advantageous near Thanksgiving, while connecting itineraries on American/United or low-cost carriers can yield savings in early November. CTA: Compare fares and baggage rules now to choose the best airline for your November LAX→DTW trip.