Typical airline options for DTW→TYR travel in September include American Airlines (often routing via Dallas/Fort Worth (DFW) with American Eagle regional partners), Delta Air Lines (connections via Atlanta (ATL) or Minneapolis (MSP) to regional carriers), and United (connections via Houston (IAH) or Chicago (ORD) to regional partners). American tends to offer the most direct regional connectivity to Tyler Pounds Regional Airport (TYR) because DFW is a primary regional hub. Delta and United can provide competitive pricing and alternate routing options. Compare baggage allowances, change fees, and loyalty program benefits (AAdvantage, SkyMiles, MileagePlus) when booking. CTA: Check airline comparisons for DTW to TYR flights in September and book the carrier that matches your priorities for price, convenience, and loyalty benefits.