Typical nonstop flights from Denver International Airport (DEN) to Pittsburgh International Airport (PIT) in October depart across a range of windows: early morning (06:00–09:00 local), midday (11:00–14:00), and evening (17:00–21:00). Average airborne time is about 3 hours 30 minutes to 4 hours; remember that Denver operates on Mountain Time (MDT/ MST depending on daylight savings) while Pittsburgh uses Eastern Time, so adjust arrival clocks accordingly. If your itinerary includes a connection, common hubs include Chicago O’Hare (ORD), Dallas/Fort Worth (DFW), or Charlotte (CLT), which can add 1–4 hours depending on layover length. For October travel, check airline schedules closely as carriers sometimes add or reduce flights around October weekends and sporting events.