Major carriers that serve Colorado Springs Airport (COS) and provide itineraries to Orlando International Airport (MCO) include American Airlines (via DFW), Delta (via ATL), United (via DEN), and Southwest (sometimes via DEN or with direct seasonal services). American offers extensive connections through DFW with competitive loyalty perks for AAdvantage members, Delta routes through ATL for strong on-time performance, United leverages Denver hub connections for frequent schedules, and Southwest is often attractive for free checked bags and flexible change policies. In October, compare overall cost, total travel time, baggage fees, and elite benefits; use multi-airline searches and book directly with the carrier that best matches your priorities for COS to MCO travel.