American, Delta, and United frequently offer competitive connecting itineraries between Cleveland Hopkins International Airport (CLE) and Manchester-Boston Regional Airport (MHT), each with different hubs, baggage rules, and loyalty benefits. American often connects via Philadelphia (PHL), Delta via Atlanta (ATL) or Detroit (DTW), and United via Newark (EWR) or Chicago (ORD); Southwest may provide regional options from CLE to Boston-area airports but typically not direct to MHT. Compare total travel time, checked bag fees, and elite status protections when choosing your November itinerary, and prioritize carriers with reliable winter operations for stress-free travel. Use fare comparisons and the airline's official pages to book November flights from Cleveland Hopkins International Airport (CLE) to Manchester-Boston Regional Airport (MHT) today.