Carriers serving passengers on the CAK→MSP corridor in September commonly include major network airlines and their regional partners. Delta Air Lines frequently offers efficient connections via Detroit (DTW) or Minneapolis (as a hub), American Airlines routes often connect through Charlotte (CLT) or Chicago (ORD), and United typically connects via Chicago or Denver. Evaluate total trip time, checked-bag fees, carry-on allowances, and elite status benefits when comparing fares. For September travel, loyalty credits, flexible ticket options, and change policies may offer added value during unpredictable schedules — prioritize whichever airline gives the best balance of price, schedule, and customer service.