Direct flights from Boston Logan International Airport (BOS) to Istanbul Airport (IST) offer the fastest, most convenient travel with minimal connection risk and easier luggage handling—ideal if you value time. Connecting flights via hubs such as London (LHR), Frankfurt (FRA), Amsterdam (AMS), Doha (DOH), or Dubai (DXB) can save money, offer flexible routing, and provide more daily schedule options, though they increase total travel time and risk of missed connections. In March, when fares may be lower, consider whether saving on price is worth an added layover; for tight itineraries or short trips, choose nonstop where available.