Delta Air Lines and Alaska Airlines are primary operators for nonstop service between Hartsfield-Jackson Atlanta International Airport (ATL) and Seattle-Tacoma International Airport (SEA), offering different loyalty programs, onboard services, and schedules. Delta often provides multiple daily nonstops with extensive connectivity via its Atlanta hub, while Alaska focuses on West Coast networks and premium economy options. When selecting an airline in October, compare total costs including seat selection and baggage fees, check frequent flyer benefits, and review on-time performance for the specific dates you plan to travel.