Major carriers serving itineraries between Ted Stevens Anchorage International Airport (ANC) and Denver International Airport (DEN) in May include Alaska Airlines, United Airlines, and Delta Air Lines—typically via connecting hubs. Alaska Airlines often routes through Seattle (SEA) or Portland (PDX) and is known for strong regional service from Anchorage. United frequently connects through Denver's own hub network and Midwest hubs like Denver and Chicago for return routings. Delta routes commonly route through Minneapolis-Saint Paul (MSP) or Salt Lake City (SLC). When comparing airlines, evaluate total travel time, connection airports, baggage fees, and loyalty program benefits. If low cost is priority, check basic economy restrictions; if comfort matters, compare first-class or premium cabin availability on the route.